If you love creamy, cheesy pasta dishes that satisfy the soul, this Chicken Alfredo Tortellini Casserole is your new go-to comfort food. Picture tender cheese-filled tortellini smothered in rich Alfredo sauce, shredded chicken for protein, and layers of gooey mozzarella and Parmesan cheese. Finished with a golden, crunchy breadcrumb topping and a sprinkle of fresh parsley, it’s a casserole that looks as good as it tastes.

Perfect for weeknight dinners, family meals, or potluck gatherings, this dish combines creamy textures, savory flavors, and a lightly crisp topping for a balance that will have everyone asking for seconds. With simple ingredients and minimal prep, it’s a restaurant-quality meal you can make in your own kitchen without stress. Whether you’re a pasta lover, a chicken enthusiast, or simply craving a warm, hearty dish, this casserole hits all the right notes.

Why You’ll Love This Recipe

Creamy and cheesy: Rich Alfredo sauce combined with mozzarella and Parmesan creates a decadent, melty texture.
Family-friendly: Even picky eaters love the cheesy tortellini and tender chicken.
Easy to prepare: Minimal prep and simple ingredients make this weeknight-friendly.
Make-ahead option: Assemble in advance for stress-free meal planning.
Crowd-pleaser: Ideal for gatherings, potlucks, or cozy family dinners.
Balanced textures: Soft tortellini, creamy sauce, and crispy breadcrumb topping make every bite satisfying.

Ingredient Breakdown

Cheese Tortellini (1 lb, cooked al dente): The base of the casserole, providing creamy cheese pockets in every bite.
Cooked Chicken (2 cups, shredded): Adds protein and pairs perfectly with the rich Alfredo sauce.
Alfredo Sauce (15 oz jar): Provides the velvety, creamy base. Homemade or store-bought works.
Sour Cream (½ cup): Adds tanginess and extra creaminess to the sauce.
Garlic Powder (1 tsp): Infuses savory flavor without extra chopping.
Black Pepper (½ tsp) & Salt (¼ tsp): Balanced seasoning to enhance all flavors.
Shredded Mozzarella (1 cup): Melts beautifully for the iconic cheese pull.
Grated Parmesan (1 cup): Adds savory depth and sharp, nutty flavor.
Panko Breadcrumbs (½ cup): Creates a light, crunchy topping.
Unsalted Butter (2 tbsp, melted): Binds the breadcrumbs and helps them brown.
Fresh Parsley (¼ cup, chopped): Adds bright herbaceous flavor and freshens the dish.

Pro Tips

Cook tortellini al dente: It will continue cooking in the oven, so slightly undercooked pasta prevents mushiness.
Use leftover or rotisserie chicken: Saves time and adds extra flavor.
Layer cheese strategically: Mix some into the sauce and reserve some for topping to get gooey inside and golden crust outside.
Grease the baking dish: Prevent sticking and ensure even cooking.
Let the casserole rest: Allowing 5 minutes to cool slightly helps it set and makes serving easier.

Ingredient Swaps and Variations

Protein alternatives: Swap chicken for turkey, ham, or even cooked shrimp.
Cheese options: Try fontina, provolone, or asiago for added depth.
Vegetable boost: Add spinach, broccoli, or sun-dried tomatoes to sneak in extra nutrients.
Spicy version: Stir in crushed red pepper flakes or hot sauce for a kick.
Gluten-free option: Use gluten-free tortellini and check sauce ingredients for gluten-free labeling.

Serving Suggestions

This casserole is hearty enough to be a meal on its own, but lighter sides balance the richness. Serve with a crisp Caesar or garden salad, roasted or steamed vegetables, or garlic bread to soak up extra sauce. For gatherings, pair with antipasto platters, bruschetta, or a light soup like minestrone to create a complete Italian-inspired meal. Leftovers make excellent lunch options, simply reheat in the oven or microwave.

Make Ahead + Storage Tips

You can assemble this casserole a few hours ahead or even the night before. Cover tightly with foil and refrigerate until ready to bake. Bake as directed, adding 5–10 minutes to cooking time if the casserole is cold from the fridge.

Leftovers can be stored in an airtight container in the refrigerator for 3–4 days. Reheat individual portions in the microwave, or warm the entire casserole at 350°F, covered, until heated through. To refresh the breadcrumb topping, sprinkle a little extra cheese and breadcrumbs before reheating in the oven.

For freezing, assemble but do not bake. Wrap tightly in foil or plastic wrap and freeze for up to 2 months. Thaw in the refrigerator overnight and bake as directed.

Cultural or Historical Notes

Alfredo sauce originated in Rome, Italy, and traditionally combines butter, heavy cream, and Parmesan cheese for a rich, indulgent sauce. Chicken Alfredo became popular in the United States as a creamy pasta entrée, often paired with fettuccine. By combining tortellini and a slow-baked, cheesy topping, this casserole transforms the classic into a comforting, American-style baked dish that’s perfect for family meals and cozy nights at home.

Frequently Asked Questions

Can I make this casserole ahead of time?
Yes! Assemble it a day in advance, refrigerate, and bake when ready. Add a few extra minutes to cook time if it’s cold.

Can I use frozen tortellini?
Yes, but slightly undercook it if boiling, or slightly increase baking time.

Can I make this vegetarian?
Absolutely. Omit chicken or use plant-based protein alternatives like chickpeas or meatless chicken strips.

Can I add more vegetables?
Yes—spinach, broccoli, zucchini, or mushrooms can be folded in before baking.

Do I have to use Alfredo sauce from a jar?
No, homemade Alfredo sauce made with butter, cream, and Parmesan works wonderfully for richer flavor.

Emily